Pesquisa ao BVS

Resultados 1-6 de 6 1. Looking back to the future--acne.
Autor(es): Cunliffe WJ
Fonte: Dermatology; 204(3): 167-72, 2002.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 12037442
Artigo Idioma(s): Inglês
Tipo de publicação: Artigo de Revista; Revisão
Assunto(s): Acne Vulgar/diagnóstico Acne Vulgar/quimioterapia Agentes Antibacterianos/uso terapêutico Agentes Dermatológicos/uso terapêutico Propionibacterium acnes/isolamento & purificação Acne Vulgar/fisiopatologia Animais Ensaios Clínicos como Assunto Dermatologia/tendências Feminino Previsões Humanos Masculino Prognóstico Propionibacterium acnes/efeitos de drogas Pesquisa Índice de Gravidade de Doença Resultado de Tratamento
Selecionar Imprimir Fotocópia 2. Antibiotic sensitivity of Propionibacterium acnes isolates from patients with acne vulgaris in a tertiary dermatological referral centre in Singapore.
Autor(es): Tan HH; Goh CL; Yeo MG; Tan ML
Fonte: Ann Acad Med Singapore; 30(1): 22-5, 2001 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 11242619
Artigo Idioma(s): Inglês
Tipo de publicação: Ensaio Clínico; Estudo Comparativo; Artigo de Revista
Resumo: OBJECTIVES: To study the minimum inhibitory concentrations (MICs) of Propionibacterium acnes (P. acnes) isolates to selected antibiotics from patients with acne vulgaris in Singapore and determine if resistance increases with prolonged use of antibiotics. DESIGN: A single-centre prospective study. SETTING: Tertiary dermatological referral centre in Singapore. PATIENTS: One hundred and fifty patients with acne vulgaris seen at the National Skin Centre. RESULTS: In patients who had never been (mais) on antibiotics, there were no resistant isolates of P. acnes. In patients who had been on short-term antibiotics (between 6 to 18 weeks), there were 2 resistant strains among the 34 isolates (6.25%); in patients who had been on antibiotics for longer periods, there were 11 resistant strains among the 51 isolates (21.6%). The differences in the rates of isolation of resistant strains between patients who had not been on antibiotics to those that had been on long-term antibiotics were statistically significant (P = 0.015). There was also a significant difference in isolation of resistant strains from those on short-term antibiotics compared to those who had been on long-term antibiotics (P = 0.036). Resistance to erythromycin was most commonly encountered. Most of the erythromycin-resistant strains also showed cross-resistance to clindamycin. The average MICs to antibiotics such as minocycline, erythromycin and clindamycin in those on long-term antibiotics were significantly higher when compared to patients who had not been on antibiotics. CONCLUSIONS: Antibiotic resistance in P. acnes isolates in Singapore follows similar patterns to studies conducted in Europe. Resistance to erythromycin was most commonly seen, and this is associated with cross-resistance to clindamycin. Among the tetracycline group of drugs, the average MICs to tetracycline was higher than that for doxycycline, which in turn was higher than that for minocycline. Antibiotic resistance can occur with short-term antibiotic courses, and the rate of resistance increases as the duration of antibiotic consumption increases.
Assunto(s): Acne Vulgar/microbiologia Agentes Antibacterianos/farmacologia Resistência Microbiana a Medicamentos Propionibacterium acnes/efeitos de drogas Acne Vulgar/quimioterapia Adulto Instituições de Assistência Ambulatorial Agentes Antibacterianos/administração & dosagem Feminino Infecções por Bactérias Gram-Positivas/quimioterapia Humanos Masculino Testes de Sensibilidade Microbiana Probabilidade Propionibacterium acnes/isolamento & purificação Referência e Consulta Sensibilidade e Especificidade Singapura
Selecionar Imprimir Fotocópia 3. Digital fluorescence as a parameter of Propionibacterium acnes suppression needs assessment.
Autor(es): Burkhart CN
Fonte: Int J Dermatol; 40(2): 101-3, 2001 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 11328389
Artigo Idioma(s): Inglês
Tipo de publicação: Artigo de Revista
Assunto(s): Acne Vulgar/diagnóstico Fluorescência Fotografia/métodos Propionibacterium acnes/crescimento & desenvolvimento Propionibacterium acnes/efeitos de radiação Humanos
Selecionar Imprimir Fotocópia 4. Propionibacterium acnes biotypes and susceptibility to minocycline and Keigai-rengyo-to.
Autor(es): Higaki S; Nakamura M; Morohashi M; Yamagishi T
Fonte: Int J Dermatol; 43(2): 103-7, 2004 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 15125499
Artigo Idioma(s): Inglês
Tipo de publicação: Estudo Comparativo; Artigo de Revista
Resumo: BACKGROUND: Propionibacterium acnes is the predominant organism in acne lesions, but the sensitivity of different biotypes of P. acnes to therapeutic agents has seldom been reported. METHODS: To characterize biotypes of P. acnes and to measure the effects of Keigai-rengyo-to (KRT) and minocycline (MINO) on clinical P. acnes isolates. RESULTS: Propionibacterium acnes biotype III (BIII) is the most common form of identified acne lesion, followed by P. acnes biotype I. BIII was isolated from m (mais) ild, moderate and severe severity and the average lipase activity of BIII was higher than that of Biotypes I, II, IV and V. No significant differences in the decrease of free fatty acid production elicited by KRT or by MINO were found between BIII and the other biotypes. The degree of decreased butyric acid production was greater than that of propionic acid production in the medium supplemented with MINO. The percent decrease of butyric acid production elicited by 1 mg/mL of KRT was the same as that elicited by 0.1 microg/mL of MINO. Among biotypes of P. acnes, the minimal inhibitory concentrations of agents tested were generally higher in erythritol-positive biotypes than in erythritol-negative biotypes. CONCLUSION: The high frequency of BIII might be responsible for the severity of acne in patients. It seems that if the same concentrations of MINO and KRT are used, the antilipase activity of MINO is stronger than that of KRT. Minocycline also has a direct anti-lipase activity against P. acnes. The mechanism underlying the influence of erythritol on the susceptibility of P. acnes to these agents remains unknown.
Assunto(s): Acne Vulgar/quimioterapia Medicamentos de Ervas Chinesas/farmacologia Minociclina/farmacologia Propionibacterium acnes/classificação Propionibacterium acnes/efeitos de drogas Acne Vulgar/microbiologia Adulto Técnica de Tipagem Bacteriana Farmacorresistência Bacteriana Feminino Humanos Masculino Medicina Kampo Testes de Sensibilidade Microbiana Medição de Risco Amostragem Sensibilidade e Especificidade
Selecionar Imprimir Fotocópia 5. Acne necroticans (varioliformis) versus Propionibacterium acnes folliculitis.
Autor(es): Maibach HI
Fonte: J Am Acad Dermatol; 21(2 Pt 1): 323, 1989 Aug.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 2527876
Artigo Idioma(s): Inglês
Tipo de publicação: Comentário; Carta
Assunto(s): Acne Vulgar/microbiologia Corynebacterium Propionibacterium acnes Acne Vulgar/diagnóstico Infecções Bacterianas Diagnóstico Diferencial Humanos
Selecionar Imprimir Fotocópia 6. A study on the characterization of Corynebacterium acnes.
Autor(es): Takizawa K
Fonte: J Dermatol; 4(5): 193-202, 1977 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 15461349
Artigo Idioma(s): Inglês
Tipo de publicação: Estudo Comparativo; Artigo de Revista
Resumo: Forty-nine strains of anaerobic gram-positive rods were used in a systematic study of their biochemical and physiological reactions and morphological characteristics and were also subjected to gas chromatographic analyses in an effort to classify them as strains of Corynebacterium acnes (C. acnes). The strains were isolated both from lesions in acne vulgaris and from normal skin. According to their biochemical and physiological characters, these 49 strains were divided into six subgroups (S (mais) ubgroup A-F). They were also separated into two morphological types. The larger of these two types included gram-positive, unevently staining pleomorphic rods (35 strains); the smaller type contained shorter coccal rods similar to Peptostreptococci (14 strains). The macroscopic appearance of the colonies of both types was the same. All strains of the smaller type showed the same biochemical and physiological characteristics which were of the saccharolytic type (Subgroup B) suggesting a close relationship between the microscopic appearance of the strains and their biochemical and physiological characteristics. Upon microscopical observation, the changing the pH of the media did not cause any transformation of the organism from one type to another. Between pH 6.0 and 6.5 all strains grew well but above pH 8.0 growth was poor. The gas chromatographic analyses demonstrated that selected sample strains from each of the six subgroups showed the same characteristic chromatograph, suggesting that they could be of the same species, i.e., C. acnes.
Assunto(s): Acne Vulgar/microbiologia Propionibacterium acnes/isolamento & purificação Propionibacterium acnes/ultraestrutura Estudos de Casos e Controles Cromatografia Gasosa Contagem de Colônia Microbiana Meios de Cultura Feminino Humanos Japão Masculino Sensibilidade e Especificidade